USMLE Prep - Medical Reference Library

Epiglottitis in Adults — Recognition & Airway Plan

System: Otolaryngology • Reviewed: Aug 31, 2025 • Step 1Step 2Step 3

Synopsis:

Adult epiglottitis presents with severe sore throat, odynophagia, and muffled voice. Prioritize airway assessment; avoid agitation; secure airway early if stridor/respiratory distress; give IV antibiotics and steroids.

Key Points

  • Stabilize ABCs; begin targeted evaluation without delaying life-saving therapy.
  • Use system-specific risk tools to guide testing and disposition.
  • Order high-yield tests first; escalate imaging when indicated.
  • Start evidence-based initial therapy and reassess frequently.

Algorithm

  1. Primary survey and vitals; IV access and monitors.
  2. Focused history/physical; identify red flags and likely etiologies.
  3. Order system-appropriate labs and imaging (see Investigations).
  4. Initiate guideline-based empiric therapy (see Pharmacology).
  5. Reassess response; arrange consultation and definitive management.

Clinical Synopsis & Reasoning

For Epiglottitis In Adults Recognition Airway Plan, frame the differential by acuity and pathophysiology, then align diagnostics to the leading hypotheses. Prioritize stabilization while obtaining high‑yield studies such as CBC (Baseline hematology), BMP (Electrolytes/renal). Incorporate bedside imaging and targeted labs to define severity and identify complications; synthesize results with clinical trajectory to refine the working diagnosis and disposition needs.


Treatment Strategy & Disposition

Initiate disease‑directed therapy alongside supportive care, titrating to objective response. Pharmacologic options commonly include Analgesia/Antipyretics. Use validated frameworks (e.g., Airway Triggers for Intubation) to guide escalation and site of care. Address precipitating factors, de‑escalate empiric therapies with data, and arrange follow‑up for monitoring and risk‑factor modification; admit patients with instability, high risk of deterioration, or needs for close monitoring.


Management Notes

Keep patient upright with supplemental oxygen. Avoid tongue depressors outside controlled environments.


Epidemiology / Risk Factors

  • Risk factors vary by condition and patient profile

Investigations

TestRole / RationaleTypical FindingsNotes
CBCBaseline hematologyAbnormal counts
BMPElectrolytes/renalDerangements

Airway Triggers for Intubation

FindingAction
Stridor or severe dyspneaIntubate in OR with backup
Rapid progressionEarly airway control
Inability to handle secretionsSecure airway
Imminent obstruction on scopeSecure airway
Stable without distressICU observation + antibiotics

Pharmacology

MedicationMechanismOnsetRole in TherapyLimitations
CeftriaxoneCephalosporinHoursAdult epiglottitis empiricAllergy
DexamethasoneGlucocorticoidHoursAirway edema reductionHyperglycemia

Prognosis / Complications

  • Prognosis depends on severity, comorbidities, and timeliness of care

Patient Education / Counseling

  • Explain red flags and when to seek emergent care.
  • Reinforce medication adherence and follow-up plan.

References

  1. Adult Epiglottitis — Link