USMLE Prep - Medical Reference Library

Soft Tissue Sarcoma — Workup & Oncologic Principles

System: General Surgery • Reviewed: Aug 31, 2025 • Step 1Step 2Step 3

Synopsis:

Suspected STS requires MRI, planned core‑needle biopsy along future incision line, and referral to a sarcoma center. Aim for wide negative margins; use neoadjuvant or adjuvant radiation for large/high‑grade tumors; stage with chest imaging.

References

  1. NCCN/ESMO STS Guidelines — Link