Key Points
- Stabilize ABCs; begin targeted evaluation without delaying life-saving therapy.
- Use system-specific risk tools to guide testing and disposition.
- Order high-yield tests first; escalate imaging when indicated.
- Start evidence-based initial therapy and reassess frequently.
Algorithm
- Primary survey and vitals; IV access and monitors.
- Focused history/physical; identify red flags and likely etiologies.
- Order system-appropriate labs and imaging (see Investigations).
- Initiate guideline-based empiric therapy (see Pharmacology).
- Reassess response; arrange consultation and definitive management.
Clinical Synopsis & Reasoning
Differentiate non‑purulent cellulitis from purulent abscess and necrotizing infections. Examine for systemic toxicity, immunosuppression, and anatomic traps (hand, perineum). Point‑of‑care ultrasound distinguishes abscess requiring drainage from phlegmon and can guide procedural planning.
Treatment Strategy & Disposition
Incise and drain purulent collections when present; choose empiric antibiotics based on local MRSA prevalence, host factors, and severity. Outline margins to assess response and elevate affected limb; arrange close follow‑up for diabetics and immunocompromised. Admit for systemic toxicity, rapid progression, or failure of oral therapy; involve surgery when necrotizing fasciitis is suspected.
Epidemiology / Risk Factors
- Risk factors vary by condition and patient profile
Investigations
| Test | Role / Rationale | Typical Findings | Notes |
|---|---|---|---|
| CBC | Baseline hematology | Abnormal counts | |
| BMP | Electrolytes/renal | Derangements |
Common Pathogens
| Organism | Note |
|---|---|
| Staphylococcus aureus | Common including MRSA |
| Gram negatives | Risk with healthcare exposure |
| Polymicrobial | IV drug use or contiguous spread |
Pharmacology
| Medication | Mechanism | Onset | Role in Therapy | Limitations |
|---|---|---|---|---|
| Cephalexin/cefazolin | β-lactam | Hours | MSSA/streptococcal coverage | Allergy |
| TMP-SMX or doxycycline | Folate antagonism / 30S | Hours | CA-MRSA coverage | Hyperkalemia / photosensitivity |
| Clindamycin | 50S inhibition | Hours | Toxin suppression (Group A strep) | C. difficile risk |
| Piperacillin-tazobactam | Broad β-lactam | Hours | Severe/nec fasc mixed coverage | AKI |
Prognosis / Complications
- Prognosis depends on severity, comorbidities, and timeliness of care
Patient Education / Counseling
- Explain red flags and when to seek emergent care.
- Reinforce medication adherence and follow-up plan.
Notes
Do not delay surgery when progressive deficits. Coordinate with anesthesia and critical care for sepsis management.