Key Points
- Use the highest‑yield diagnostic test early; do not let testing delay time‑critical therapy.
- Set objective targets (hemodynamic, neurologic, respiratory) and reassess frequently.
- Plan definitive source control or disease‑specific therapy when indicated; document follow‑up and patient education.
Algorithm
- Assess clinical risk; order US (peds/pregnancy) or CT A/P for adults if uncertain.
- Start IV fluids, analgesia, and pre‑op antibiotics.
- Proceed to laparoscopic appendectomy for most; discuss antibiotics‑first option in selected uncomplicated cases.
- If perforation/abscess → drain/antibiotics; delayed appendectomy case‑by‑case; plan follow‑up.
Clinical Synopsis & Reasoning
Start with clinical risk assessment; obtain ultrasound in children/pregnancy and CT with contrast in adults when diagnosis uncertain. Provide pre‑op antibiotics and pain control; proceed to laparoscopic appendectomy for uncomplicated cases or consider antibiotics‑first in selected patients with shared decision making.
Treatment Strategy & Disposition
Stabilize ABCs. Initiate guideline‑concordant first‑line therapy with precise dosing and continuous monitoring. Escalate to advanced/procedural interventions based on explicit failure criteria. Define ICU, step‑down, and ward disposition triggers; involve specialty teams early.
Epidemiology / Risk Factors
- Risk varies by comorbidity and precipitants; see citations for condition‑specific data.
Investigations
| Test | Role / Rationale | Typical Findings | Notes |
|---|---|---|---|
| Ultrasound (children/pregnancy) or CT A/P with contrast | Diagnosis | Noncompressible tubular structure; periappendiceal fat stranding | CT most accurate in adults |
| CBC/CRP | Inflammation | Leukocytosis, elevated CRP | Adjunct |
| Urinalysis/pregnancy test | Differential | Exclude GU causes | — |
Pharmacology
| Medication/Intervention | Mechanism | Onset | Role in Therapy | Limitations |
|---|---|---|---|---|
| Ceftriaxone + Metronidazole (pre‑op) | Antibiotics | Hours | Coverage for gut flora | Tailor if perforated |
| Analgesia and IV fluids | Supportive | Immediate | Optimize for OR | — |
| Antibiotics‑first strategy (selected) | Non‑operative | Days | Shared decision in uncomplicated appendicitis | Recurrence risk |
Prognosis / Complications
- Outcome depends on timeliness of diagnosis and definitive therapy; monitor for complications.
Patient Education / Counseling
- Provide red‑flag education, adherence guidance, and explicit return precautions; arrange timely specialty follow‑up.
References
- WSES Jerusalem Guidelines for Acute Appendicitis (2020) — Link