USMLE Prep - Medical Reference Library

Acute Cholecystitis - Imaging with Ultrasound and HIDA

System: Radiology • Reviewed: Aug 31, 2025 • Step 1Step 2Step 3

Synopsis:

Use right upper quadrant ultrasound as first line; when equivocal, consider HIDA scan or CT based on acuity and alternate diagnoses.

Key Points

  • Stabilize ABCs; begin targeted evaluation without delaying life-saving therapy.
  • Use system-specific risk tools to guide testing and disposition.
  • Order high-yield tests first; escalate imaging when indicated.
  • Start evidence-based initial therapy and reassess frequently.

Algorithm

  1. Primary survey and vitals; IV access and monitors.
  2. Focused history/physical; identify red flags and likely etiologies.
  3. Order system-appropriate labs and imaging (see Investigations).
  4. Initiate guideline-based empiric therapy (see Pharmacology).
  5. Reassess response; arrange consultation and definitive management.

Clinical Synopsis & Reasoning

For Acute Cholecystitis Imaging Ultrasound Hida, frame the differential by acuity and pathophysiology, then align diagnostics to the leading hypotheses. Prioritize stabilization while obtaining high‑yield studies such as CBC (Baseline hematology), BMP (Electrolytes/renal). Incorporate bedside imaging and targeted labs to define severity and identify complications; synthesize results with clinical trajectory to refine the working diagnosis and disposition needs.


Treatment Strategy & Disposition

Initiate disease‑directed therapy alongside supportive care, titrating to objective response. Pharmacologic options commonly include Analgesia/Antipyretics. Use validated frameworks (e.g., Key Ultrasound Signs) to guide escalation and site of care. Address precipitating factors, de‑escalate empiric therapies with data, and arrange follow‑up for monitoring and risk‑factor modification; admit patients with instability, high risk of deterioration, or needs for close monitoring.


Epidemiology / Risk Factors

  • Risk factors vary by condition and patient profile

Investigations

TestRole / RationaleTypical FindingsNotes
CBCBaseline hematologyAbnormal counts
BMPElectrolytes/renalDerangements

Key Ultrasound Signs

FindingImplication
Stones with shadowingCholelithiasis
Wall thickening or pericholecystic fluidInflammation
Positive sonographic MurphyHigh likelihood

Pharmacology

MedicationMechanismOnsetRole in TherapyLimitations
Piperacillin-tazobactamβ-lactam/β-lactamase inhibitorHoursSevere biliary infectionAKI
Ceftriaxone + metronidazoleCephalosporin + nitroimidazoleHoursModerate diseaseAllergy
Analgesia/antiemeticSymptomatic controlMinutesSupportive careSedation; QT (ondansetron)

Prognosis / Complications

  • Prognosis depends on severity, comorbidities, and timeliness of care

Patient Education / Counseling

  • Explain red flags and when to seek emergent care.
  • Reinforce medication adherence and follow-up plan.

Notes

Tailor imaging to patient stability and availability. Avoid delays in unstable patients needing source control.


References

  1. ACR Appropriateness Criteria - Right Upper Quadrant Pain — Link
  2. RSNA overview for gallbladder imaging — Link