USMLE Prep - Medical Reference Library

Hydrofluoric Acid Burns — Calcium Rescue

System: Burn Surgery • Reviewed: Aug 31, 2025 • Step 1Step 2Step 3

Synopsis:

HF causes liquefaction necrosis and systemic hypocalcemia/hyperkalemia. Immediate irrigation and calcium therapy (topical/intradermal/IV) are lifesaving.

Key Points

  • Stabilize ABCs; begin targeted evaluation without delaying life-saving therapy.
  • Use system-specific risk tools to guide testing and disposition.
  • Order high-yield tests first; escalate imaging when indicated.
  • Start evidence-based initial therapy and reassess frequently.

Algorithm

  1. Primary survey and vitals; IV access and monitors.
  2. Focused history/physical; identify red flags and likely etiologies.
  3. Order system-appropriate labs and imaging (see Investigations).
  4. Initiate guideline-based empiric therapy (see Pharmacology).
  5. Reassess response; arrange consultation and definitive management.

Clinical Synopsis & Reasoning

For Burn Surgery Hydrofluoric Acid Burns, frame the differential by acuity and pathophysiology, then align diagnostics to the leading hypotheses. Prioritize stabilization while obtaining high‑yield studies such as CBC (Baseline hematology), BMP (Electrolytes/renal). Incorporate bedside imaging and targeted labs to define severity and identify complications; synthesize results with clinical trajectory to refine the working diagnosis and disposition needs.


Treatment Strategy & Disposition

Initiate disease‑directed therapy alongside supportive care, titrating to objective response. Pharmacologic options commonly include Analgesia/Antipyretics. Use validated frameworks (e.g., Calcium Rescue Options) to guide escalation and site of care. Address precipitating factors, de‑escalate empiric therapies with data, and arrange follow‑up for monitoring and risk‑factor modification; admit patients with instability, high risk of deterioration, or needs for close monitoring.


Management Notes

Keep pre‑mixed calcium gel kits accessible in high‑risk industries. Use non‑latex gloves; HF penetrates certain materials.


Epidemiology / Risk Factors

  • Risk factors vary by condition and patient profile

Investigations

TestRole / RationaleTypical FindingsNotes
CBCBaseline hematologyAbnormal counts
BMPElectrolytes/renalDerangements

Calcium Rescue Options

RouteUse
Topical gel 2.5%First‑line for minor skin
Intradermal Ca gluconatePersistent pain/whitening
Intra‑arterialSevere fingertip/hand burns
Nebulized CaInhalation exposures
IV calciumSystemic toxicity/cardiac changes

Pharmacology

MedicationMechanismOnsetRole in TherapyLimitations
Silver sulfadiazine (topical)AntimicrobialHoursPartial-thickness burnsLeukopenia; sulfa allergy
AnalgesicsPain controlMinutesBurn painSedation
Tetanus prophylaxisVaccine/IG per statusHoursAs indicatedLocal rxn

Prognosis / Complications

  • Prognosis depends on severity, comorbidities, and timeliness of care

Patient Education / Counseling

  • Explain red flags and when to seek emergent care.
  • Reinforce medication adherence and follow-up plan.

References

  1. HF Protocols — Link