USMLE Prep - Medical Reference Library

Functional Neurological Disorder — Recognition & Management

System: Neurology • Reviewed: Aug 31, 2025 • Step 1Step 2Step 3

Synopsis:

Diagnose using positive signs (Hoover’s sign, tremor entrainment) — not by exclusion. Early explanation and FND‑informed physiotherapy/CBT improve outcomes; avoid unnecessary repeated investigations.

Key Points

  • Stabilize ABCs; begin targeted evaluation without delaying life-saving therapy.
  • Use system-specific risk tools to guide testing and disposition.
  • Order high-yield tests first; escalate imaging when indicated.
  • Start evidence-based initial therapy and reassess frequently.

Algorithm

  1. Primary survey and vitals; IV access and monitors.
  2. Focused history/physical; identify red flags and likely etiologies.
  3. Order system-appropriate labs and imaging (see Investigations).
  4. Initiate guideline-based empiric therapy (see Pharmacology).
  5. Reassess response; arrange consultation and definitive management.

Clinical Synopsis & Reasoning

For Functional Neurological Disorder Recognition Management, frame the differential by acuity and pathophysiology, then align diagnostics to the leading hypotheses. Prioritize stabilization while obtaining high‑yield studies such as CT Head (NC) (Hemorrhage exclusion), Glucose (POC) (Exclude hypoglycemia), MRI Brain (selected) (Ischemia/structural). Incorporate bedside imaging and targeted labs to define severity and identify complications; synthesize results with clinical trajectory to refine the working diagnosis and disposition needs.


Treatment Strategy & Disposition

Initiate disease‑directed therapy alongside supportive care, titrating to objective response. Pharmacologic options commonly include Thrombolytic (eligible), Antiepileptics. Use validated frameworks (e.g., Examples of Positive Signs) to guide escalation and site of care. Address precipitating factors, de‑escalate empiric therapies with data, and arrange follow‑up for monitoring and risk‑factor modification; admit patients with instability, high risk of deterioration, or needs for close monitoring.


Management Notes

Use collaborative language emphasizing legitimacy of symptoms. Avoid repetitive imaging/EMGs once diagnosis is secure.


Epidemiology / Risk Factors

  • Hypertension, AF, atherosclerosis; prior stroke/TIA

Investigations

TestRole / RationaleTypical FindingsNotes
CT Head (NC)Hemorrhage exclusionAcute bloodFirst-line
Glucose (POC)Exclude hypoglycemiaLowTreat promptly
MRI Brain (selected)Ischemia/structuralDiffusion restriction

Examples of Positive Signs

SignInterpretation
Hoover’s signInconsistent weakness with preserved effort
Tremor entrainmentTremor modulates with rhythm
Collapsing weaknessInconsistent give‑way strength
Variable gaitImproves with distraction
Eyes closed unresponsivenessPreserved reflexes, inconsistent features

Pharmacology

MedicationMechanismOnsetRole in TherapyLimitations
AcetaminophenAnalgesic/antipyreticHoursSymptom control as appropriateHepatotoxicity (overdose)
Ondansetron5-HT3 antagonismMinutesAntiemesis if neededQT prolongation

Prognosis / Complications

  • Outcome tied to time-to-reperfusion; aspiration/DVT risks

Patient Education / Counseling

  • Explain red flags and when to seek emergent care.
  • Reinforce medication adherence and follow-up plan.

References

  1. FND Society Recommendations — Link