USMLE Prep - Medical Reference Library

Heat Stroke — Rapid Cooling and Organ Support

System: Emergency Medicine • Reviewed: Aug 31, 2025 • Step 1Step 2Step 3

Synopsis:

Life threatening hyperthermia with CNS dysfunction; initiate whole body cold water immersion or other rapid cooling and support airway, circulation, and complications.

Key Points

  • Stabilize ABCs; begin targeted evaluation without delaying life-saving therapy.
  • Use system-specific risk tools to guide testing and disposition.
  • Order high-yield tests first; escalate imaging when indicated.
  • Start evidence-based initial therapy and reassess frequently.

Algorithm

  1. Primary survey and vitals; IV access and monitors.
  2. Focused history/physical; identify red flags and likely etiologies.
  3. Order system-appropriate labs and imaging (see Investigations).
  4. Initiate guideline-based empiric therapy (see Pharmacology).
  5. Reassess response; arrange consultation and definitive management.

Clinical Synopsis & Reasoning

For Heat Stroke Rapid Cooling, frame the differential by acuity and pathophysiology, then align diagnostics to the leading hypotheses. Prioritize stabilization while obtaining high‑yield studies such as CBC/BMP (Baseline labs), CXR/targeted imaging (Common ED complaints), Troponin/EKG (chest pain) (ACS rule-out). Incorporate bedside imaging and targeted labs to define severity and identify complications; synthesize results with clinical trajectory to refine the working diagnosis and disposition needs.


Treatment Strategy & Disposition

Initiate disease‑directed therapy alongside supportive care, titrating to objective response. Pharmacologic options commonly include Analgesics, Antiemetics. Use validated frameworks (e.g., Cooling Options (Ranked)) to guide escalation and site of care. Address precipitating factors, de‑escalate empiric therapies with data, and arrange follow‑up for monitoring and risk‑factor modification; admit patients with instability, high risk of deterioration, or needs for close monitoring.


Epidemiology / Risk Factors

  • Varies by presentation; age/comorbidities matter

Investigations

TestRole / RationaleTypical FindingsNotes
CBC/BMPBaseline labsAbnormalities
CXR/targeted imagingCommon ED complaintsFindings vary
Troponin/EKG (chest pain)ACS rule-outMI changesUse risk tools

Cooling Options (Ranked)

MethodNotes
Cold water immersionFastest, preferred in exertional heat stroke
Evaporative with fans and mistAlternative when immersion not possible
Ice packs to groin/axilla/neckAdjunct, slower alone

Pharmacology

MedicationMechanismOnsetRole in TherapyLimitations
BenzodiazepineGABA-A potentiationMinutesControl shivering/agitation during coolingRespiratory depression
Isotonic fluidsVolume expansionHoursSupportiveFluid overload
Avoid antipyreticsN/AImmediateIneffective in heat stroke

Prognosis / Complications

  • Outcomes tied to emergency and timeliness of care

Patient Education / Counseling

  • Explain red flags and when to seek emergent care.
  • Reinforce medication adherence and follow-up plan.

Notes

Avoid antipyretics; they are ineffective. Consider benzodiazepines for shivering and agitation.


References

  1. Wilderness Medical Society Heat Illness Guidance — Link
  2. CDC Extreme Heat Clinical Resources — Link