Key Points
- Use the highest‑yield diagnostic test early; do not let testing delay time‑critical therapy.
- Set objective targets and reassess frequently.
- Plan definitive source control or disease‑specific therapy when indicated; document follow‑up and patient education.
Algorithm
- Identify rhabdomyolysis; start aggressive fluids and monitor urine output.
- Treat electrolytes (esp. K+); evaluate for compartment syndrome.
- Address causes (trauma, exertion, toxins, statins); plan disposition based on CK/renal function.
Clinical Synopsis & Reasoning
Muscle injury with marked CK elevation leads to myoglobin-induced AKI and electrolyte disturbances. Initiate early aggressive isotonic fluids, monitor and treat hyperkalemia and hypocalcemia, and consider urine alkalinization selectively; identify and remove precipitating factors.
Treatment Strategy & Disposition
Stabilize ABCs. Initiate guideline‑concordant first‑line therapy with precise dosing and continuous monitoring. Escalate to advanced/procedural interventions based on explicit failure criteria. Define ICU, step‑down, and ward disposition triggers; involve specialty teams early.
Epidemiology / Risk Factors
- Risk varies by comorbidity and precipitants; see citations for condition‑specific data.
Investigations
| Test | Role / Rationale | Typical Findings | Notes |
|---|
| Serum CK, electrolytes, creatinine, urinalysis | Diagnosis | CK often >5× ULN; heme-positive dipstick with few RBCs | Monitor trends |
| EKG and telemetry | Safety | Detect hyperkalemia-induced arrhythmias | — |
| Compartment pressure (if suspected) | Complication | Compartment syndrome | Surgical eval |
High-Risk & Disposition Triggers
| Trigger | Why it matters | Action |
|---|
| CK >5000–10000 IU/L with rising creatinine | AKI risk | Aggressive fluids; monitor K+; ICU if severe |
| Hyperkalemia/arrhythmias | Life-threatening | Standard hyperkalemia protocol; telemetry |
| Compartment syndrome | Limb threat | Surgical eval |
| Toxin exposure (statins, cocaine) | Recurrence risk | Stop offending agents; manage complications |
| Anuria or refractory acidosis | Dialysis indication | Nephrology consult |
Pharmacology
| Medication/Intervention | Mechanism | Onset | Role in Therapy | Limitations |
|---|
| Isotonic fluids (e.g., LR/NS) 200–400 mL/h, titrate to urine output 200–300 mL/h | Renal protection | Hours | Reduce AKI risk | Avoid volume overload |
| Manage hyperkalemia per protocol; avoid routine calcium unless symptomatic | Electrolytes | Minutes | Prevent arrhythmia | — |
| Urine alkalinization with bicarbonate (selected) | Adjunct | Hours | May reduce pigment nephropathy | Evidence mixed |
Prognosis / Complications
- Outcome depends on timeliness of diagnosis and definitive therapy; monitor for complications.
Patient Education / Counseling
- Provide red‑flag education, adherence guidance, and explicit return precautions; arrange timely specialty follow‑up.
References
- Rhabdomyolysis reviews and emergency nephrology guidance — Link